2010 NFL Pre-Season Picks
San Francisco 49ers vs. Indianapolis Colts
Pick: San Francisco Giants -3 -120 odds
Visit Touthouse.com for more expert NFL football picks from Doc’s Sports

Free Play from Doc’s Sports. #277 Take San Francisco over Indianapolis (Sunday 1 pm NFL Network) Very seldom do you see a road team favored by this many points during the preseason. The reason is the quarterback rotation and the 49ers have a major edge once the Colts replace Peyton Manning in the first quarter of this afternoon game. After Manning expect to see a combination of Curtis Painter, Tom Brandstater, and Tom Hiller. Longtime back-up QB Jim Sorgi has moved onto the Giants to play under Eli Manning and that leaves a major void for the Colts once Manning is out of the game. Curtis Painter had limited action late during the regular season last year and played terrible. The 49ers have Alex Smith and David Carr as their first two quarterbacks and both of them have started many games in the league. That will allow them to be up at halftime and coast to a victory in the second half. Mike Singletary is 3-1 in preseason action during his tenure. Jim Caldwell is 1-3 in his four preseason games. Doc’s Sports has you covered with a full slate of Week 1 winners and now is the time to jump on board a veteran handicapper with 39 years of experience.

If you enjoyed this article then you may be interested in:

1. Indianapolis Colts vs. San Francisco 49ers Pick, Odds & Point Spread: November 1st 2009
2. Free NFL Pick: San Francisco 49ers vs. Dallas Cowboys Odds: August 29th 2009
3. NFL Pre-Season Odds & Betting Picks: August 8th 2008
4. NFL Pre-Season Football Betting Picks & Odds for August 9th 2008
5. NFL Football Pre-Season Betting: Seahawks vs. Chargers: August 25th 2008