Chicago will look to Carlos Zambrano on Opening Day in Houston. The right-hander made 30 starts last year and posted a 14-6 record with a 3.91 earned run average. Zambrano pitched 188 2/3 innings in the 2008 season, his lowest since pitching 108 1/3 innings in 2002. Oswalt, who is coming off a WBC start for Team USA, put up a 17-10 record with a 3.54 ERA in 32 starts last season. He is also familiar with the opposing team and touts a career 12-11 record and a 3.88 ERA in 25 starts against the Chicago Cubs. Houston was victorious nine of the 17 games against Chicago last season.

5dimes.com baseball oddsmakers currently have the Chicago Cubs set as -115 moneyline favorites against the Houston Astros with the games over/under posted at 8 total runs

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Here are some baseball betting trends to consider for this game:
Cubs are 8-2 in their last 10 road games vs. a left-handed starter.
Cubs are 14-5 in their last 19 games vs. a left-handed starter.
Cubs are 9-4 in their last 13 vs. National League Central.
Astros are 10-3 in their last 13 home games vs. a right-handed starter.
Astros are 21-7 in their last 28 home games.
Astros are 21-7 in their last 28 vs. National League Central.

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